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Zolpidem is used to treat insomnia (difficulty falling asleep or staying asleep). Zolpidem belongs to a class of medications called sedative-hypnotics. It works by slowing activity in the brain to allow sleep. Buy Ambien 10mg Without Prescription
Buy Ambien 10mg Without Prescription
What is Ambien and how is it used?
Ambien is a prescription medicine used to treat the symptoms of insomnia. Ambien may be used alone or with other medications.
Ambien belongs to a class of drugs called Sedative/Hypnotics, Insomnia.
It is not known if Ambien is safe and effective in children.
AMBIEN contains zolpidem tartrate, a gamma-aminobutyric acid (GABA) A receptor positive modulator of the imidazopyridine class. AMBIEN is available in 5 mg and 10 mg strength tablets for oral administration.
Chemically, zolpidem is N,N,6-trimethyl-2-p-tolylimidazo[1,2-a] pyridine-3-acetamide L-(+)-tartrate (2:1). It has the following structure:
Zolpidem tartrate is a white to off-white crystalline powder that is sparingly soluble in water, alcohol, and propylene glycol. It has a molecular weight of 764.88.
Each AMBIEN tablet includes the following inactive ingredients: hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, and titanium dioxide. The 5 mg tablet also contains FD&C Red No. 40, iron oxide colorant, and polysorbate 80.
How does Ambien Belbien, Zolpidem work?
Belbien tablets contain the active ingredient Zolpidem, which is a type of medicine called a non-benzodiazepine hypnotic. It acts in the brain to aid sleep.
Zolpidem works by acting on receptors in the brain called GABA receptors, specifically the GABA-A receptors. This causes the release of a neurotransmitter called GABA in the brain.
Zolpidem can be used as a short-term treatment for insomnia. This includes difficulty falling asleep, waking in the night, waking early in the morning and sleeping problems that are causing severe distress.
Zolpidem decreases the time is taken to fall asleep and night-time awakenings, as well as increases the total amount of time spent sleeping. However, it is only suitable for short-term treatment of insomnia (up to four weeks), as when used for longer periods it has a potential for dependence and addiction.
What is Belbien?
Belbien is a sedative, also called a hypnotic. It affects chemicals in your brain that may become unbalanced and cause sleep problems (insomnia).
Belbien is used to treat insomnia. The immediate-release forms of Belbien are Belbien, Belbien, Edluar, and Belbien, which are used to help you fall asleep. The extended-release form of Belbien is Belbien, which has a first layer that dissolves quickly to help you fall asleep, and a second layer that dissolves slowly to help you stay asleep.
Belbien, Edluar, and Belbien are used to help you fall asleep when you first go to bed. Belbien is used to help you fall back to sleep if you wake up in the middle of the night and then have trouble sleeping.
Belbien (Belbien tartrate)Oral Spray (Belbien tartrate) is indicated for the short-term treatment of insomnia characterized by difficulties with sleep initiation. Belbien tartrate has been shown to decrease sleep latency for up to 35 days in controlled clinical studies. The clinical trials performed in support of efficacy were 4-5 weeks in duration with the final formal assessments of sleep latency performed at the end of treatment.
Uses of Belbien in details
Belbien is used to treat sleep problems such as difficulty falling asleep, waking in the middle of the night, waking too early in adults that are causing distress and affecting everyday life.
Belbien is a prescription short-acting nonbenzodiazepine hypnotic that potentiates gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, by binding to benzodiazepine receptors which are located on the gamma-aminobutyric acid receptors. Belbien is used for the short-term treatment of insomnia. It works quickly (usually within 15 minutes) and has a short half-life (2-3 hours).
The dose of Belbien (Belbien tartrate oral spray) should be individualized. Dosage in adults the recommended dose for adults is 10 mg once daily immediately before bedtime. The total Belbien (Belbien tartrate oral spray) dose should not exceed 10 mg per day.
Special populations of elderly or debilitated patients may be especially sensitive to the effects of Belbien tartrate. Patients with hepatic insufficiency do not clear the drug as rapidly as normal subjects. The recommended dose of Belbien (Belbien tartrate oral spray) in both of these patient populations is 5 mg once daily immediately before bedtime.
Use with CNS depressants dosage adjustment may be necessary when Belbien (Belbien tartrate oral spray) is combined with other CNS-depressant drugs because of the potentially additive effects.
AdministrationBelbien (Belbien tartrate oral spray) is packaged in a child-resistant container. For detailed instructions on how to use Belbien (Belbien tartrate oral spray), refer to the Patient Instructions for Use (following the Medication Guide).
Belbien (Belbien tartrate oral spray) must be primed before it is used for the first time. To prime, patients should be told to point the black spray opening away from their face and other people and spray 5 times.
Dosage Forms And StrengthsBelbien (Belbien tartrate oral spray) is available as a clear, colourless, and cherry flavoured solution designed to be sprayed directly into the mouth over the tongue. Each metered actuation (one spray) of Belbien delivers 5 mg of Belbien tartrate in 100 μL. Two actuations deliver 10 mg of Belbien tartrate.
After the initial priming of 5 actuations, there is 60 metered actuation in each child-resistant container. The total number of available doses is dependent on the number of actuations per dose (1 or 2 actuation) and the frequency of priming.
Storage And Handling Belbien (Belbien tartrate oral spray) is available in a child-resistant container. Each container includes a child-resistant cap and base with a metered-dose pump assembly and clears over the cap.
Each container contains 8.2 g of product formulation. One and two actuations of Belbien are equal to 5 and 10 mg of Belbien tartrate, respectively. There is 60 metered actuation per container after 5 initial priming actuations. Belbien (Belbien tartrate oral spray) is supplied as:
KEEP OUT OF REACH OF CHILDREN.
CNS-Active DrugsBelbien tartrate was evaluated in healthy volunteers in single-dose interaction studies for several CNS drugs. A study involving haloperidol and Belbien revealed no effect of haloperidol on the pharmacokinetics or pharmacodynamics of Belbien.
Imipramine in combination with Belbien produced no pharmacokinetic interaction other a 20% decrease in peak levels of imipramine, but there was an additive effect of decreased alertness.
Similarly, chlorpromazine in combination with Belbien produced no pharmacokinetic interaction, but there was an additive effect of decreased alertness and psychomotor performance. The lack of a drug interaction following single-dose administration does not predict a lack following chronic administration.
When multiple doses of Belbien and fluoxetine at steady-state concentrations were evaluated in healthy females, the only significant change was a 17% increase in the Belbien half-life. There was no evidence of an additive effect in psychomotor performance.
A study involving cimetidine/Belbien and ranitidine/Belbien combinations revealed no effect of either drug on the pharmacokinetics or pharmacodynamics of Belbien. Belbien had no effect on digoxin kinetics and did not affect prothrombin time when given with warfarin in normal subjects. Ivadals sedative/hypnotic effect was reversed by flumazenil; however, no significant alterations in Belbien pharmacokinetics were found.
Belbien side effects
The following serious adverse reactions in Belbien-treated patients are discussed in greater detail in other sections of the labelling:
- CNS-depressant effects and next-day impairment
- Serious anaphylactic and anaphylactoid reactions
- Abnormal thinking and behavioural changes, and complex behaviours
- Withdrawal effects
The second study was a 4-week, parallel-group at-home study in 295 patients (201 female and 94 male; median age 43 years) of 3.5 mg of Belbien compared to placebo, used on an as-needed basis after spontaneous middle-of-the-night awakenings (Study 2). In Study 2, patients took Belbien during the night on 62% of study nights.
Gastrointestinal Disorders 4% 2% Nausea 1% 1% General Disorders and Administration Site Conditions 3% 0% Fatigue 1% 0% Nervous System Disorders 5% 3% Headache 3% 1% Postmarketing Experience
The following adverse reactions have been identified during post-approval use of Belbien. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to establish a causal relationship to drug exposure.
- Application site reactions, primarily in the sublingual area, have been reported. These application site reactions included oral ulcers, blisters, and mucosal inflammation.
In January 2013, the Food and Drug Administration (FDA) lowered the recommended dose for Belbien. If you have taken Belbien in the past, your doctor may direct you to take a lower dose of this medicine than you did before.
Belbien may impair your thinking or reactions. You may still feel sleepy the morning after taking Belbien, especially if you take the extended-release tablet, or if you are a woman. Wait at least 4 hours or until you are fully awake before you do anything that requires you to be awake and alert.
Some people using this medicine have engaged in activities such as driving, eating, or making phone calls and later have no memory of the activity. If this happens to you, stop taking Belbien and talk with your doctor about another treatment for your sleep disorder.
Do not take this medicine if you have consumed alcohol during the day or just before bed.
Belbien may be habit-forming. Keep the medication in a place where others cannot get to it.
Belbien may cause a severe allergic reaction. Stop taking Belbien and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
• This medicine causes drowsiness and impairs concentration and alertness. These effects may continue into the following day and are made worse by drinking alcohol. If you are affected you should avoid potentially hazardous tasks such as driving or operating machinery. Do not drink alcohol when taking this medicine.
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